参考文献
[1] ventus therapeutics launches with $60 million series a. https://www.businesswire.com/news/home/20200506005211/en/ventus-therapeutics-launches-60-million-series (2020).
[2] quench bio closes $50m series a financing to advance first-in-class medicines targeting gasdermin to treat severe inflammatory diseases. https://quenchbio.com/press/quench-bio-closes-50m-series-a-financing-to-advance-first-in-class-medicines-targeting-gasdermin-to-treat-severe-inflammatory-diseases/ (2020).
[3] bergsbaken, t., fink, s. l. & cookson, b. t. pyroptosis: host cell death and inflammation. nature reviews microbiology 7, 99-109 (2009).
[4] shi, j. et al. cleavage of gsdmd by inflammatory caspases determines pyroptotic cell death. nature 526, 660-665 (2015).
[5] kayagaki, n. et al. caspase-11 cleaves gasdermin d for non-canonical inflammasome signalling. nature 526, 666-671 (2015).
[6] ding, j. et al. pore-forming activity and structural autoinhibition of the gasdermin family. nature 535, 111-116 (2016).
[7] broz, p., pelegrín, p. & shao, f. the gasdermins, a protein family executing cell death and inflammation. nature reviews immunology, 1-15 (2019).
[8] masson, d. & tschopp, j. a family of serine esterases in lytic granules of cytolytic t lymphocytes. cell 49, 679-685 (1987).
[9] heusel, j. w., wesselschmidt, r. l., shresta, s., russell, j. h. & ley, t. j. cytotoxic lymphocytes require granzyme b for the rapid induction of dna fragmentation and apoptosis in allogeneic target cells. cell 76, 977-987 (1994).
[10] lowin, b., hahne, m., mattmann, c. & tschopp, j. cytolytic t-cell cytotoxicity is mediated through perforin and fas lytic pathways. nature 370, 650-652 (1994).
[11] darmon, a. j., nicholson, d. w. & bleackley, r. c. activation of the apoptotic protease cpp32 by cytotoxic t-cell-derived granzyme b. nature 377, 446-448 (1995).
[12] chowdhury, d. & lieberman, j. death by a thousand cuts: granzyme pathways of programmed cell death. annu. rev. immunol. 26, 389-420 (2008).
[13] masson, d., nabholz, m., estrade, c. & tschopp, j. granules of cytolytic t‐lymphocytes contain two serine esterases. the embo journal 5, 1595-1600 (1986).
[14] zhou, z. et al. granzyme a from cytotoxic lymphocytes cleaves gsdmb to trigger pyroptosis in target cells. science (2020).
[15] zhang, z. et al. gasdermin e suppresses tumour growth by activating anti-tumour immunity. nature 579, 415-420 (2020).
[16] wang, q. et al. a bioorthogonal system reveals antitumour immune function of pyroptosis. nature 579, 421-426 (2020).
